Getting Pregnant With Factor V

Factor V Leiden causes blood to clot irregularly, causing mild to severe blood clotting with symptoms ranging from pain and swelling to shortness of breath and a rapid heartbeat. According to the Mayo Clinic website, women taking estrogen or who are pregnant are at an increased risk for developing Factor V Leiden.

  1. Significance

    • Factor V Leiden affects between 3 and 10 percent of the caucasian population through heterozygous mutations, notes Jennifer Rosenberg's article "Pregnancy, Clotting, and Factor V Leiden." Women with heterozygous Factor V Leiden have a three to 10 time greater risk of developing a blood clot than a person without Factor V Leiden, while women with homozygous Factor V Leiden have a 30 to 140 time greater risk of a clot.

    Considerations

    • Women who have Factor V Leiden are able to get pregnant, though they may be encouraged not to by some doctors, as pregnancy increases a woman's odds of having a blood clot leading to a deep vein thrombosis or a pulmonary embolism. Jennifer Rosenberg notes that Factor V Leiden may also lead to other complications such as miscarriage, stillbirth and preeclampsia.

    Warning

    • Pregnancies in women who have been diagnosed with Factor V Leiden are considered high risk and often require special treatment plans to ensure a healthy pregnancy. The Mayo Clinic suggests that pregnant women with Factor V Leiden ensure that their medical provider monitors the condition and the pregnancy carefully.

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